After high school, Graham enrolled in extension classes at the University of California, Los Angeles (UCLA) where she studied English for two years.

Her first high-profile starring role came in the Corey Haim/Corey Feldman vehicle License to Drive (1988), as a popular girl named Mercedes Lane, who serves as the love interest of Haim's character.

Her efforts won her a Young Artist Award nomination in the Best Young Actress in a Motion Picture Comedy or Fantasy category.

In 1999, she co-starred in Bowfinger and Austin Powers: The Spy Who Shagged Me.

In the 2000s, Graham starred in films Committed (2000), Say It Isn't So (2001), Mary (2005), Gray Matters (2007), The Hangover (2009) and its sequel, The Hangover Part III (2013).

The cast received a nomination for the Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture.

The same year, she also starred in the Gregg Araki film Nowhere, and had a cameo in the horror hit Scream 2.The 2000 film Committed was her first starring vehicle.She played Joline, a devoted-beyond-reason young wife looking for the husband who left her.They relocated often, as a result of their father's occupation, and Heather became increasingly shy. Heather Joan Graham (born January 29, 1970) is an American actress, director, and writer.In 1986, she appeared on a special "Teen Week" episode of the NBC game show Scrabble.